Dr. Amy Nett: Okay, so let me go back and look at that one. So, case number four. Okay. Case number four, this is a patient we said SIBO, abdominal distension, pre-diabetes, metabolic dysfunction, and weight loss resistance. She had high total cortisol, and she’s favoring cortisone. It’s surprising, and it doesn’t fit. Unfortunately, sometimes that’s the case. I don’t know how to explain why she’s not. We can certainly see a general pattern for things such as obesity, insulin, and inflammation, but unfortunately, there are probably even more factors than we’re aware of, so you’re saying, “How do I understand how insulin resistance or metabolic syndrome would technically affect the cortisol presentation?” Well, yeah, so there it is exactly. There is how it can typically affect favoring cortisol or cortisone, but then potentially other things come into play. Again, here, unfortunately, I don’t think I mentioned what the thyroid function looked like. You always want to check thyroid function because that could be influencing it. Here you do have increased clearance, and increased clearance—let’s see—it could be affected by the high insulin and the obesity, so that fits, but what I think you’re saying and your point of confusion is she is favoring cortisone over cortisol. There you might look at a couple things. Since she is possibly overweight, you might look at her E2, if she has really high estradiol. That could be favoring cortisone. Also see what supplements she is taking, if she is taking something such as magnolia already.