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HPA Axis

HPA Axis

Reading from this week’s recommendations, wondering if acetyl-CoA is connected to the supplement from the HPA dysfunction protocol acetyl-CH. Taking it, and I realize I don’t know much about the mechanisms by which we think it works.

Chris Kresser: Acetyl-CH is related in the sense that it’s really targeting acetylcholine. But it’s not the same and it’s...

Apex product NeuroFlam NT is recommended for high melatonin in the HPA-D treatment protocol. NeuroFlam is a very similar Apex product that additionally contains resveratrol and things like green tea extracts. I’ve yet to read or hear your take on resveratrol. Similar to curcumin, boswellia, etc.?

Chris Kresser: My take is that from what I’ve seen, supplemental resveratrol falls into the category of many supplemental antioxidants,...

If DUTCH is supposed to check the hormonal rhythms of a typical day, why discontinue coffee during collection if that’s part of a patient’s day? DUTCH collection sheets request stopping caffeine. Can one cup of decaf affect DUTCH? What about a small piece of dark chocolate?

Chris Kresser: It’s meant to affect a normal day, but caffeine has a rather immediate effect and so it’s recommended...

In a case study from the HPA-D unit, you mentioned a patient with high cortisol, high cortisol metabolites, high cortisone, and additionally that the patient had eye floaters. Have you noticed any underlying dysfunction specifically related to eye floaters?

Chris Kresser: I have noticed the correlation between HPA-D and eye floaters and I think just in layperson’s terms there...

I have a patient with a DUTCH first reading with low cortisol, low cortisone. Second reading was high cortisol, high cortisone after exercising. Third reading was within range. Fourth reading, cortisol was within range and high end of range cortisone. Her 24-hour cortisol and cortisone are above range, high end of range. This appears to be a result of the significantly elevated second reading, with a low first morning cortisol and significantly elevated second morning reading. What would be the best treatment strategy? She is being treated for hypothyroid, and we are currently doing an antimicrobial protocol.

Dr. Amy Nett: What are her symptoms, I think, would be my question? Let me try to summarize here. So,...

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