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A 41-year-old female, ongoing mood symptoms. Mother of three, history of childhood asthma and allergies, antibiotics. Has been on prednisone for nine months for worsening asthma and respiratory infections. Currently on 7.5 mg with plan for a reduction to 5 mg, but patient’s anxious. Because every time they reduce it, she feels she does poorly in terms of respiratory health. Not been able to exercise as she develops palpitations, feels that she’s out of shape. Sleeping less than seven hours due to prednisone, increases her background anxiety. HIstory of childhood trauma. Been gluten and dairy-free for many years. Has eliminated soy and corn as well. Brain fog, difficulty with focus and concentration, anxiety, mood symptoms, also cramps. How to best support her in the context of the prednisone taper. Like her to do CSA and Cyrex testing as well as host of labs. However many of her labs would be skewed by the prednisone. I’m not up to speed in GI testing. Recommended 30-day reset along with autoimmune diet as well as addition of magnesium, curcumin, l’theanine, and probiotic. I’d like to know her D level and supplement as needed as well as her TFT, TPO status. Any words of wisdom re: prednisone or taper, her workout post-steroid treatment, and how to best support that transition re: HPA axis?

Chris Kresser:  Yeah. So in situations like this, you really have to dial in the diet and lifestyle first more...

Question today has to do with taking Meriva, a Thorne product which is supposed to be bioactive curcumin. I took two caps every two to four hours, and I had migraines, but it never helped me. So I often had to take ibuprofen. Is that because that particular form of curcumin is not well absorbed in my body? Or just that curcumin is not anti inflammatory for me? If not what else can I use when I have a migraine or neck muscle aches instead of ibuprofen? I seem to need this almost daily.

Chris Kresser:  Curcumin doesn’t work like ibuprofen, in my experience, in that you can’t typically use it acutely. It works...

Does Relora formula that we talked about in the HPA axis unit have a specific mechanism of lowering cortisol that would specifically target belly fat? Since you mentioned Relora’s relation, in relation to belly fat, I’m wondering if it acts differently or its general possible effect as it is in other substances that may lower cortisol such as phosphatidylserine.

Chris Kresser:  More the latter. I don’t know of any specific effect of Relora that would be related to body...

Nootropics becoming very popular. How do you feel about nootropics, and which, if any, are you recommending?

Chris Kresser:  In general, I’m a fan, not surprisingly, of identifying the underlying issue, and I think our bodies are...

Have you found any main causes for calcitrate candida in your practice? We recently saw a patient with positive candida on Doctor’s Data and markers for yeast and organic acids. Was treated with A-FNG for almost three months. Patient got better on A-FNG, but within a week of being off it, the symptoms returned. Patient’s also very dependent on molybdenum. Once she gets off, she has very sore and stiff muscles. Any thoughts?

Chris Kresser:  It’s a good question. I mean, mold exposure comes to mind certainly as one possibility there if the...
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